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CRYSTAL SHEDDING IN SEPTIC ARTHRITIS: CASE REPORTS AND IN VIVO EVIDENCE IN AN ANIMAL MODEL

Identifieur interne : 003440 ( Main/Exploration ); précédent : 003439; suivant : 003441

CRYSTAL SHEDDING IN SEPTIC ARTHRITIS: CASE REPORTS AND IN VIVO EVIDENCE IN AN ANIMAL MODEL

Auteurs : T. P. Gordon ; C. Reid ; M. A. M. Rozenbilds ; M. Ahern

Source :

RBID : ISTEX:B5BD9D9FD664732093F47ED25B24C12DE42AB503

English descriptors

Abstract

Abstract Two cases of coexisting septic and crystalline joint disease are reported. In one patient polyarticular septic artaritis occurred simultaneously with gout and pseudogout. In a second patient septic arthritis preceded the appearance of calcium pyrophosphate dihydrate (CPPD) crystals in the joint fluid, supporting an earlier postulate that lysosomal enzymes released during sepsis lead to shedding of crystals from cartilage and synovium into the joint space. This sequence was demonstrated in a rat air pouch model of synovium, in which CPPD crystals embedded in facsimile synovial tissue were released after injection of pyogenic bacteria. Coexisting septic arthritis should always be considered when crystals are identified in inflamed joints, particularly in elderly patients with concurrent infections.

Url:
DOI: 10.1111/j.1445-5994.1986.tb01181.x


Affiliations:


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Le document en format XML

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<term>Acute inflammation</term>
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<term>Arch intern</term>
<term>Arthritis</term>
<term>Arthritis rheum</term>
<term>Articular cartilage</term>
<term>Aust</term>
<term>Book review</term>
<term>Calcium pyrophosphate dihydrate</term>
<term>Cartilage</term>
<term>Cppd</term>
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<term>Elderly patients</term>
<term>Extracellular rhomboidal crystals</term>
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<term>Foreign body giant cells</term>
<term>Gout</term>
<term>Gram stain</term>
<term>Joint aspiration</term>
<term>Joint fluid</term>
<term>Joint sepsis</term>
<term>Joint space</term>
<term>Lysosomal enzymes</term>
<term>Numerous intracellular</term>
<term>Polarised light</term>
<term>Positive birefringence</term>
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<term>Pouch formation</term>
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<term>Purulent fluid</term>
<term>Pyogenic bacteria</term>
<term>Renal failure</term>
<term>Right elbow</term>
<term>Right index finger</term>
<term>Septic</term>
<term>Septic arthritis</term>
<term>Septic process</term>
<term>Simultaneous gout</term>
<term>Staphylococcus aureus</term>
<term>Streptococcus pyogenes</term>
<term>Subcutaneous injection</term>
<term>Superficial necrosis</term>
<term>Synovium</term>
<term>White cell count</term>
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<div type="abstract" xml:lang="en">Abstract Two cases of coexisting septic and crystalline joint disease are reported. In one patient polyarticular septic artaritis occurred simultaneously with gout and pseudogout. In a second patient septic arthritis preceded the appearance of calcium pyrophosphate dihydrate (CPPD) crystals in the joint fluid, supporting an earlier postulate that lysosomal enzymes released during sepsis lead to shedding of crystals from cartilage and synovium into the joint space. This sequence was demonstrated in a rat air pouch model of synovium, in which CPPD crystals embedded in facsimile synovial tissue were released after injection of pyogenic bacteria. Coexisting septic arthritis should always be considered when crystals are identified in inflamed joints, particularly in elderly patients with concurrent infections.</div>
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